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Keppra and cbd oil : Epilepsy - I have had 5 focal seizures which last from 5-30 seconds. I am now on 1500 xr keppra in the a.m and same for p.m. My doctor continues to raise my dosage of keppra but the seizures continue to occur. I was wondering if anyone has tried anti-epileptic cbd oil with keppra and has had any success. Cannabis Oil & Getting off the Keppra | Osito News Nov 04, 2014 · After about 2 months on CBD oil (medical marijuana), we have drastically decreased Simon's dose of Keppra, a very harmful anti-epileptic. He gets 350 milligrams a day - less than half his old intake (750 mg), and we're slowly decreasing it each week. Not only is Keppra known to cause long-term cognitive decline, its short… Smoking Marijuana while on Keppra? : Epilepsy I'm on keppra, and ive been smoking high CBD strains of marijuana from the dispensary, as opposed to the usual THC-heavy strains. THC usually gives me anxiety. BUT here's the important part: it doesn't really help much with my seizures, but it helps IMMENSELY with some of the drepression and confusion that comes with keppra.